The suppression of OTUD7B by miR‐491‐5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non‐small cell lung cancer
Overall, our study first proved that miR-491-5p impedes VM by suppressing OUTD7B and promoting the ubiquitination of VEGFA. The miR-491-5p/OTUD7B axis may be a novel target for antiangiogenic therapy in NSCLC.
Authors
- Chenxin Yan
- Bin Ke (ORCID: https://orcid.org/0000-0001-6242-9898)
- Xiaofei Chen (ORCID: https://orcid.org/0000-0002-6252-5879)
- Lin Shi
- Hai Zhong (ORCID: https://orcid.org/0000-0002-7014-7871)
- Lijun He
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Zhujiang Hospital (CN)
- Dongguan People’s Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/jgm.3743
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province