I<sub>2</sub>-Mediated [3 + 3] Annulation for the Construction of Indole-Pyrimidine-Pyrazole-Fused Tetracyclic Heteroarenes
An I<sub>2</sub>-mediated annulation of 3-aminopyrazoles with indole-3-carboxaldehydes has been demonstrated for the first time. This tandem strategy allows the facile construction of indole-pyrimidine-pyrazole-fused tetracyclic heteroarenes that are otherwise inaccessible by the existing methods. These fused heterocycles exhibited enhanced antifungal activities against <i>Valsa mali</i> and <i>Botryosphaeria dothidea</i> compared with commercial Xemium fungicide.
Authors
- Kun Xu (ORCID: https://orcid.org/0000-0002-0419-8822)
- Heng-Tong Qu
- Cheng‐Tao Feng (ORCID: https://orcid.org/0000-0001-5539-9221)
- Jiaxin Yang (ORCID: https://orcid.org/0000-0002-1355-4729)
- Fan Teng (ORCID: https://orcid.org/0000-0003-0761-4227)
- Jia-Hui Hong
- Long-Sheng Zhou
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Beijing University of Technology (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1021/acs.joc.4c01934
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- Natural Science Foundation of Anhui Province
- Beijing Municipal Natural Science Foundation