TRPC5-mediated NLRP3 inflammasome activation contributes to myocardial cell pyroptosis in chronic intermittent hypoxia rats
These findings indicated that the pyroptosis response increases in CIH-induced myocardial injury, and the mechanism that TRPC5 is upregulated, promoting the expression of NLRP3 and inflammasome formation through CaMKII phosphorylation and HDAC4 cytoplasmic translocation. This might be a potential target for the treatment of OSA-induced myocardial injury.
Authors
- Wen Wen (ORCID: https://orcid.org/0000-0002-1966-7222)
- Zhiqiang Li (ORCID: https://orcid.org/0009-0007-8786-5945)
- Mengmeng Wang (ORCID: https://orcid.org/0000-0001-8833-8644)
- Yulan Chen (ORCID: https://orcid.org/0009-0006-5006-6675)
- Li Yu (ORCID: https://orcid.org/0000-0001-6872-2665)
- Sharezhati Yishajiang
- Gulinazi Tulahong
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Acta cardiologica. Supplementum
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1080/00015385.2024.2408137
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China