Bacterial-like inflammatory response in children with adenovirus leads to inappropriate antibiotic use: a multicenter cohort study
Interestingly, our data suggests that HAdV-infected children exhibit a more pronounced inflammatory response despite experiencing less severe respiratory symptoms compared to other viruses. The presence of prolonged fever and a strong inflammatory response often leads to antibiotic overuse during the initial phase, when the viral etiology is yet to be confirmed. Early and accurate identification of HAdV infection is crucial to optimize treatment strategies and minimize unnecessary antibiotic use.
Authors
- Eugenia Bruzzese (ORCID: https://orcid.org/0000-0002-8578-729X)
- Agnese Tamborino (ORCID: https://orcid.org/0009-0009-2278-1120)
- Maria Moriondo (ORCID: https://orcid.org/0000-0001-9653-8371)
- Liana Punzi
- Chiara Albano (ORCID: https://orcid.org/0000-0003-4544-154X)
- Laura Petrarca (ORCID: https://orcid.org/0000-0002-2430-2981)
- Cristina Moracas
- Alfredo Diana
- Claudia Colomba (ORCID: https://orcid.org/0000-0003-3245-9396)
- Amelia Licari (ORCID: https://orcid.org/0000-0002-1773-6482)
- Marta Stracuzzi (ORCID: https://orcid.org/0000-0003-2899-3190)
- Marco Poeta (ORCID: https://orcid.org/0000-0002-7515-1394)
- Luisa Galli (ORCID: https://orcid.org/0000-0002-7912-3366)
- Gian Luigi Marseglia (ORCID: https://orcid.org/0000-0003-3662-0159)
- Anna Condemi
- Ester Del Tufo
- Teresa Di Fraia
- Alfredo Guarino (ORCID: https://orcid.org/0000-0003-0199-0336)
- Andrea Lo Vecchio (ORCID: https://orcid.org/0000-0003-4181-6842)
- Vania Giacomet
- Fabio Midulla
- Stefano Linsalata
- Francesca Grieco
- Simona Marra
- Eleonora Ardia
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- Luigi Sacco Hospital (IT)
- Meyer Children's Hospital (IT)
- Federico II University Hospital (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Città della Speranza Foundation (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Infection
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1007/s15010-024-02405-8
- Citations
- 5
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Università degli Studi di Napoli Federico II