Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study
Genetically predicted inhibition of HMGCR is linked with the progression of kidney function decline, while genetically predicted PCSK9 inhibition is negatively associated with kidney function decline. Future research should incorporate clinical trials to validate the relevance of PCSK9 in preventing kidney function decline.
Authors
- Zhicheng Zhao (ORCID: https://orcid.org/0000-0001-6506-7298)
- Shuo Ying
- Yu Wan (ORCID: https://orcid.org/0000-0002-8354-7647)
- Yu Song (ORCID: https://orcid.org/0000-0002-9092-8958)
- Haoyu Meng (ORCID: https://orcid.org/0000-0001-6179-4762)
- Naikuan Fu
- Han Fu
- Peng Zhang (ORCID: https://orcid.org/0009-0004-7146-1805)
Institutions
- Tianjin University (CN)
- Sir Run Run Shaw Hospital (CN)
- Tianjin Chest Hospital (CN)
- Tianjin Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s12920-024-02020-4
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.65