Combination of Losartan and Platinum Nanoparticles with Photothermal Therapy Induces Immunogenic Cell Death Effective Against Neuroblastoma
This study demonstrated that losartan-induced fibroblasts ablation increased the penetration of MPNs into tumors. Enhanced penetration allowed PTT to kill more tumor cells and synergistically activate immune cells, leading to ICD, indicating the great promise of the strategy for treating neuroblastoma in vivo.
Authors
- Ying Zhao (ORCID: https://orcid.org/0000-0002-7160-6662)
- Zhaogang Teng (ORCID: https://orcid.org/0000-0001-8792-764X)
- Jiang Wu (ORCID: https://orcid.org/0000-0002-9796-9533)
- Fan Qiu (ORCID: https://orcid.org/0009-0002-7610-4271)
- Tangyao Sun (ORCID: https://orcid.org/0009-0003-3831-7572)
- Feng Wang
- Xiaojun Zhang (ORCID: https://orcid.org/0000-0002-4559-0177)
- Yu Wang (ORCID: https://orcid.org/0000-0002-9071-0238)
- Jun Tao (ORCID: https://orcid.org/0000-0003-3892-4199)
Institutions
- Nanjing University of Posts and Telecommunications (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/ijn.s467968
- Citations
- 6
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.11