Silencing the glycerol-3-phosphate acyltransferase-1 gene in the liver of mice fed a high-fat diet, enhances insulin sensitivity and glucose metabolism by promoting fatty acid beta-oxidation
Silencing GPAT1, and thereby reducing glycerolipid synthesis, promotes β-oxidation and ameliorates HFD-induced hepatic insulin resistance, confirming the enzyme's pivotal role in liver metabolic dysfunction associated with increased lipid supply.
Authors
- Piotr Zabielski (ORCID: https://orcid.org/0000-0002-4901-5217)
- Kamila Roszczyc-Owsiejczuk (ORCID: https://orcid.org/0000-0001-5296-5582)
- Karolina Pogodzińska
- Agnieszka Błachnio‐Zabielska (ORCID: https://orcid.org/0000-0002-8055-0576)
- Monika Imierska (ORCID: https://orcid.org/0000-0002-0994-0408)
Institutions
- Medical University of Białystok (PL)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1016/j.biopha.2024.117531
- Citations
- 1
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Narodowe Centrum Nauki