The Evolutionary Forest of Pancreatic Cancer
Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.
Authors
- Matthew A. Myers (ORCID: https://orcid.org/0000-0002-9337-5180)
- Marc A. Attiyeh (ORCID: https://orcid.org/0000-0002-9949-1449)
- Simone Zaccaria (ORCID: https://orcid.org/0000-0002-5265-7392)
- Akimasa Hayashi (ORCID: https://orcid.org/0000-0002-7424-8127)
- Brian J. Arnold (ORCID: https://orcid.org/0000-0002-8629-5465)
- Hitomi Sakamoto (ORCID: https://orcid.org/0000-0002-5688-7806)
- Benjamin J. Raphael (ORCID: https://orcid.org/0000-0003-1274-048X)
- Caitlin A. McIntyre (ORCID: https://orcid.org/0000-0002-7206-2433)
- Alvin P. Makohon-Moore (ORCID: https://orcid.org/0000-0002-4781-3565)
- Joanne F. Chou (ORCID: https://orcid.org/0000-0002-6866-2022)
- Laura DeLong Wood (ORCID: https://orcid.org/0000-0003-3096-652X)
- Amanda Zucker (ORCID: https://orcid.org/0000-0002-9283-7072)
- Christine A. Iacobuzio–Donahue (ORCID: https://orcid.org/0000-0002-4672-3023)
- Marinela Capanu (ORCID: https://orcid.org/0000-0003-4953-3193)
- Nicholas D. Socci (ORCID: https://orcid.org/0000-0002-8254-6925)
- Katelyn Mullen (ORCID: https://orcid.org/0000-0002-4894-855X)
- Jungeui Hong (ORCID: https://orcid.org/0009-0009-5998-2102)
- Haochen Zhang (ORCID: https://orcid.org/0000-0002-8292-9491)
- Zachary A. Kohutek (ORCID: https://orcid.org/0009-0005-3220-6673)
Institutions
- Cedars-Sinai Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- Kyorin University (JP)
- Princeton University (US)
- Johns Hopkins Medicine (US)
- Kettering University (US)
- Hackensack Meridian Health (US)
- Johns Hopkins Hospital (US)
- University College London (GB)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1158/2159-8290.cd-23-1541
- Citations
- 20
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.65
Funders
- Memorial Sloan-Kettering Cancer Center
- Cycle for Survival
- Daiichi-Sankyo
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- National Institutes of Health
- National Cancer Institute