Autologous stem cell transplant in Jehovah’s Witness: The last hope for survival

Abstract: A 55-year-old female, belonging to Jehovah’s Witness community, had to undergo autologous stem transplantation (ASCT), the last ultimate option for her chemoresistant multiple myeloma. Due to her religious faith, she did not consent to transfusing blood components throughout her treatment course, which made the situation medically and ethically challenging. We, as a multidisciplinary team, formulated an individualized treatment algorithm, counseling sessions, and various special documentation to take the treatment plan forward. Risk–benefit analysis and contingency planning were crucial in her case as it was a one-of-a-kind experience. This bloodless ASCT was successful by means of thoughtful waiting, guarded management, and alternatives to blood components.