Antiangiogenic effects in the modulation of inflammatory pathways. A comprehensive analysis of potential therapeutic substances
Based on current knowledge antiangiogenic compounds are utilized in the treatment of inflammatory-depended diseases such as cancer. It has been shown that these compounds can simultaneously block several signalling pathways regulating angiogenesis. The visualization of fluorescently labelled F-actin and VE-cadherin was allowed to demonstrate that the reorganization of the cell cytoskeleton disrupts cellular processes and consequently inhibits angiogenesis.
Authors
- Klaudia Piekarska (ORCID: https://orcid.org/0000-0003-4853-8822)
- Klaudia Bonowicz (ORCID: https://orcid.org/0000-0002-2098-2799)
- Maciej Gagat (ORCID: https://orcid.org/0000-0002-5445-8821)
- Alina Grzanka (ORCID: https://orcid.org/0000-0002-2593-098X)
- Dominika Spyt
- Dominika Jerka (ORCID: https://orcid.org/0009-0005-3777-598X)
Institutions
- Nicolaus Copernicus University (PL)
- Collegium Medicum in Bydgoszcz (PL)
Publication Details
- Journal
- Medical Research Journal
- Published
- 2024-10-08
- DOI
- https://doi.org/10.5603/mrj.101851
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00