Characterization of <i>Pseudomonas aeruginosa</i> from subjects with diffuse panbronchiolitis
Diffuse panbronchiolitis (DPB), a chronic lung disease characterized by persistent <i>P. aeruginosa</i> infection, serves as an informative comparator to more common chronic lung diseases, such as cystic fibrosis (CF). This study aimed to better address the interplay between <i>P. aeruginosa</i> and chronically compromised airway environments through the examination of DPB <i>P. aeruginosa</i> strains, as existing literature regarding DPB is limited to case reports, case series, and clinical treatment guidelines. The evaluation of these features in the context of DPB, in tandem with prevailing knowledge of <i>P. aeruginosa</i> strains collected from more common chronic lung diseases (e.g., CF), can aid in the development of more effective strategies to combat respiratory <i>P. aeruginosa</i> infections in patients with chronic lung diseases.
Authors
- Yohei Doi (ORCID: https://orcid.org/0000-0002-9620-2525)
- Hyojik Yang (ORCID: https://orcid.org/0000-0002-1659-2771)
- Robert K. Ernst (ORCID: https://orcid.org/0000-0001-5016-8694)
- Matthew E. Sherman (ORCID: https://orcid.org/0000-0003-4918-6179)
- Joanna B. Goldberg (ORCID: https://orcid.org/0000-0002-5285-5188)
- Dina A. Moustafa (ORCID: https://orcid.org/0000-0002-9616-5947)
- Casey E. Hofstaedter (ORCID: https://orcid.org/0000-0003-2798-1382)
- David A. Rasko (ORCID: https://orcid.org/0000-0002-7337-7154)
- Charles M. Met (ORCID: https://orcid.org/0009-0009-4209-4723)
- Ian P. O’Keefe (ORCID: https://orcid.org/0000-0003-1151-3242)
- C. Sweet (ORCID: https://orcid.org/0000-0003-4712-1398)
Institutions
- University of Maryland, Baltimore (US)
- Emory University (US)
- University of Pittsburgh (US)
- United States Naval Academy (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1128/spectrum.00530-24
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Cystic Fibrosis Foundation
- National Institutes of Health
- School of Dentistry, University of Maryland
- National Institute of Allergy and Infectious Diseases