Variability of macrolide-resistant profile in <i>Mycobacterium avium</i> complex pulmonary disease
This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with <i>Mycobacterium avium</i> complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
Authors
- Daisuke Motooka (ORCID: https://orcid.org/0000-0002-4616-9608)
- Eriko Fukui (ORCID: https://orcid.org/0000-0003-3800-1327)
- Shizuo Akira (ORCID: https://orcid.org/0000-0001-7602-9617)
- Yuko Abe (ORCID: https://orcid.org/0000-0003-3438-4201)
- Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
- Yasuharu Nagahama (ORCID: https://orcid.org/0000-0003-0662-5688)
- Takayuki Niitsu (ORCID: https://orcid.org/0000-0003-4280-3074)
- Tadayoshi Nitta
- Shota Nakamura (ORCID: https://orcid.org/0000-0003-2058-5942)
- Kiyoharu Fukushima (ORCID: https://orcid.org/0000-0002-9767-7899)
- Hiroshi Kida (ORCID: https://orcid.org/0000-0002-9351-7855)
- Yasushi Shintani (ORCID: https://orcid.org/0000-0002-2540-5288)
- Hiroshi Nabeshima (ORCID: https://orcid.org/0009-0006-5893-8255)
- Sho Komukai (ORCID: https://orcid.org/0000-0002-4329-2520)
- Yuki Matsumoto (ORCID: https://orcid.org/0000-0002-2911-308X)
- Kazuki Hashimoto (ORCID: https://orcid.org/0000-0002-8324-2202)
- Seigo Kitada (ORCID: https://orcid.org/0000-0002-6368-0686)
- Keisuke Miki (ORCID: https://orcid.org/0000-0002-5351-8319)
- Kazuyuki Tsujino
- Takanori Matsuki
- Takuro Nii
- June Yamauchi
- Haruko Saito
Institutions
- Toneyama National Hospital (JP)
- National Hospital Organization (JP)
- Osaka International University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1128/aac.01213-24
- Citations
- 3
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- GlaxoSmithKline
- Takeda Science Foundation
- Japan Agency for Medical Research and Development
- Japan Intractable Diseases Research Foundation
- Foundation of Kinoshita Memorial Enterprise
- Ministry of Education, Culture, Sports, Science and Technology
- Inamori Foundation
- Shionogi
- Senri Life Science Foundation
- Japanese Respiratory Society
- MSD Life Science Foundation, Public Interest Incorporated Foundation
- Japan Society for the Promotion of Science