Can the Mineralization of Antibiotics from Water Bodies be a Significant Step in the Fight Against Alarming Antimicrobial Resistance?

Introduction: The overuse and improper disposal of antibiotics may add to the continuous rise of antimicrobial resistance (AMR). In this work, we demonstrate a sequential effect of two novel catalytic systems consisting of MIL-100(Fe) MOF (Metal Organic Framework) and MnO2 nanosheets to degrade amoxicillin antibiotic through the destruction of β lactam group. Method: The catalysts were fabricated via chemical method. the catalysts exhibit large surface area, excellent porosity, excellent catalytic activity, and insolubility and can be easily separable from the reaction mixture. Results: The sequential use of MIL-100(Fe) MOF and MnO2 nanosheets could showcase 92% degradation of amoxicillin within 1.5 hours under ambient conditions without any significant residual bi-product as confirmed by LCMS studies. Conclusion: Impressively, the antimicrobial susceptibility of degraded residue is lessened by 33% as compared to pure amoxicillin.