Global analysis of neuropeptide receptor conservation across phylum Nematoda
The repertoire of C. elegans peptide GPCR orthologs varies across phylogenetic clades and several peptide GPCRs show broad conservation in the phylum Nematoda. Our work functionally characterizes the conserved receptors NPR-9 and NPR-16 as the respective GPCRs for the AstA-like NLP-1 peptides and the AstC-related peptide NLP-99. NLP-1 and NLP-99 are widely conserved in nematodes and their representation matches that of their receptor in most species. These findings demonstrate the conservation of a functional Gal/AstA and SST/AstC signaling system in nematodes. Our dataset of C. elegans peptide GPCR orthologs also lays a foundation for further functional studies of peptide GPCRs in the widely diverse nematode phylum.
Authors
- Elke Vandewyer (ORCID: https://orcid.org/0000-0003-1774-1764)
- Luca Golinelli (ORCID: https://orcid.org/0000-0002-6484-8284)
- Ellen Geens (ORCID: https://orcid.org/0000-0001-6117-2648)
- Louise E. Atkinson (ORCID: https://orcid.org/0000-0002-5184-2676)
- Allister Irvine
- Ciaran J. McCoy
- Angela Mousley
- Liesbet Temmerman (ORCID: https://orcid.org/0000-0002-1249-3995)
- Isabel Beets (ORCID: https://orcid.org/0000-0002-0968-4360)
Institutions
- Queen's University Belfast (GB)
- KU Leuven (BE)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s12915-024-02017-6
- Citations
- 5
- Primary Topic
- Parasite Biology and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Onderzoeksraad, KU Leuven
- Vlaamse regering
- National Institutes of Health
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council
- European Research Council