α1 <sub>C</sub> S1928 Phosphorylation of Ca <sub>V</sub> 1.2 Channel Controls Vascular Reactivity and Blood Pressure
Results suggest an essential role for α1<sub>C</sub> S1928 phosphorylation in regulating channel distribution, activity and gating modality, and vascular function during angiotensin II signaling and hypertension. Phosphorylation of this single vascular α1<sub>C</sub> amino acid could be a risk factor for hypertension that may be targeted for therapeutic intervention.
Authors
- Peter H. Bartels (ORCID: https://orcid.org/0000-0001-5852-1835)
- Eleonora Grandi (ORCID: https://orcid.org/0000-0002-4401-8857)
- Chao‐Yin Chen
- Navid Singhrao (ORCID: https://orcid.org/0000-0001-7438-2409)
- Sergi Simó (ORCID: https://orcid.org/0000-0002-8344-0313)
- Johannes Hell (ORCID: https://orcid.org/0000-0001-7960-7531)
- Miguel A. S. Martín‐Aragón Baudel (ORCID: https://orcid.org/0000-0001-9399-4013)
- Jade Taylor (ORCID: https://orcid.org/0000-0001-7158-2712)
- Ye Chen‐Izu (ORCID: https://orcid.org/0000-0003-4818-9570)
- Lu Ren (ORCID: https://orcid.org/0000-0002-9731-8562)
- Víctor A. Flores-Tamez (ORCID: https://orcid.org/0000-0001-8369-9192)
- Arsalan U. Syed
- Manuel F. Navedo (ORCID: https://orcid.org/0000-0001-6864-6594)
- Madeline Nieves‐Cintrón (ORCID: https://orcid.org/0000-0003-1935-8400)
- Victoria Ramer
- Thanhmai Le
- Gopireddy R. Reddy (ORCID: https://orcid.org/0000-0002-6944-1491)
- Kwun Nok Mimi Man (ORCID: https://orcid.org/0000-0002-0132-9129)
- Mary C. Horne (ORCID: https://orcid.org/0000-0002-2799-3212)
- Eamonn J. Dickson (ORCID: https://orcid.org/0000-0001-8619-7630)
- Stefano Morotti (ORCID: https://orcid.org/0000-0001-8679-665X)
- Luis F. Santana (ORCID: https://orcid.org/0000-0002-4297-8029)
- Junyoung Hong (ORCID: https://orcid.org/0000-0002-7261-2204)
- Wendy R. Lemus‐Martinez
- Yumna Moustafa
Institutions
- University of California, Davis (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1161/jaha.124.035375
- Citations
- 8
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22