HLA diversity unveils susceptibility and organ-specific occurrence of second primary cancers: a prospective cohort study
These results suggest that HLA alleles may serve as biomarkers for the susceptibility and organ-specific occurrence of SPC, while dietary modulation may mitigate hazardous alleles-related SPC risk, potentially aiding in the early prediction and prevention of SPC.
Authors
- Zi-Xuan Rong (ORCID: https://orcid.org/0000-0001-5686-0796)
- Duan-Duan Han (ORCID: https://orcid.org/0000-0001-8718-2174)
- Jia-Run Lin (ORCID: https://orcid.org/0009-0002-5082-0552)
- Dehua Wu (ORCID: https://orcid.org/0000-0003-0560-0016)
- Lushan Xiao (ORCID: https://orcid.org/0000-0002-8387-6336)
- Zhong‐Yi Dong (ORCID: https://orcid.org/0000-0001-9967-0060)
- Si-Cong Ma (ORCID: https://orcid.org/0000-0003-0834-0328)
- Yan-Pei Zhang (ORCID: https://orcid.org/0000-0002-8025-5681)
- Xiao-Ting Cai (ORCID: https://orcid.org/0000-0001-9989-3571)
- Wei Wei (ORCID: https://orcid.org/0000-0001-5929-7409)
- Yuan‐Yuan Wang (ORCID: https://orcid.org/0000-0001-9589-2977)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5549-4509)
- Qin Zeng (ORCID: https://orcid.org/0000-0002-5993-628X)
- He-San Luo (ORCID: https://orcid.org/0000-0003-4153-7683)
- Xue Bai (ORCID: https://orcid.org/0000-0003-0170-9305)
Institutions
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Hubei University of Arts and Science (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shantou Central Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s12916-024-03676-6
- Citations
- 1
- Primary Topic
- Multiple and Secondary Primary Cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province