Ursodeoxycholic Acid for Trans Intestinal Cholesterol Excretion Stimulation: A Randomized Placebo Controlled Crossover Study
UDCA in combination with ezetimibe increased plasma bile acid hydrophilicity in healthy subjects with LDL cholesterol levels >2.6 mmol/L but did not result in increased fecal neutral sterols or decreased LDL cholesterol. This suggests that TICE is not stimulated by an increase in the hydrophilicity of the bile acid pool in humans.
Authors
- Albert K. Groen
- G. Kees Hovingh (ORCID: https://orcid.org/0000-0002-8145-1676)
- Aldo Grefhorst (ORCID: https://orcid.org/0000-0003-1761-9494)
- Folkert Kuipers (ORCID: https://orcid.org/0000-0003-2518-737X)
- Reindert F. Oostveen (ORCID: https://orcid.org/0000-0001-7182-2886)
- Yannick Kaiser (ORCID: https://orcid.org/0000-0001-6869-0042)
- Erik S. G. Stroes
- Merel L. Hartgers (ORCID: https://orcid.org/0000-0001-8447-1114)
- Laurens F. Reeskamp (ORCID: https://orcid.org/0000-0002-8043-951X)
- Emma C. E. Meessen (ORCID: https://orcid.org/0000-0002-9416-1539)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1161/jaha.124.035259
- Citations
- 3
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.72