Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long‐QT Syndrome Type 3
We demonstrated that patient-derived and genetically engineered LQT3 hiPSC-derived cardiomyocytes faithfully recapitulate pathologic characteristics of LQT3. The clinical significance of such an in vitro model is in the exploration of novel therapeutic strategies, stratifying drug adverse reaction risk and potentially facilitating a more targeted, patient-specific approach in high-risk patients with LQT3.
Authors
- Rui Li (ORCID: https://orcid.org/0000-0002-9425-0523)
- Joseph Galvin (ORCID: https://orcid.org/0000-0002-3617-8738)
- Deirdre Ward (ORCID: https://orcid.org/0000-0002-3583-4641)
- Catherine McGorrian
- Veronica McInerney (ORCID: https://orcid.org/0000-0003-4586-4091)
- Stephen T. O'Brien
- Ning Ge (ORCID: https://orcid.org/0000-0001-8407-2439)
- Sanbing Shen (ORCID: https://orcid.org/0000-0002-8217-9811)
- Timothy O’Brien (ORCID: https://orcid.org/0000-0001-9028-5481)
- Terence Prendiville (ORCID: https://orcid.org/0000-0002-3824-636X)
- Min Liu
- Wenxin Xia
Institutions
- Northwestern University (US)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Tallaght University Hospital (IE)
- Mater Misericordiae University Hospital (IE)
- Children's Health Ireland at Crumlin (IE)
- National Children’s Research Centre (IE)
- Hebei Normal University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1161/jaha.124.034690
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.40