Single cell spatial profiling of FFPE splenic tissue from a humanized mouse model of HIV infection
This study found that the CosMx SMI platform is valuable for assessing HIV infection and providing insights into host biomarkers associated with HIV reservoirs. Higher relative expression of the SYK gene in aviremic-infected cells from the humanized mouse HIV model was consistent with levels found in CD4 + T cells of aviremic donors.
Authors
- Carol Cheney (ORCID: https://orcid.org/0000-0002-4149-3791)
- Luca Sardo (ORCID: https://orcid.org/0000-0002-6491-5088)
- Mark Gregory (ORCID: https://orcid.org/0000-0003-4149-4724)
- Brian C. Magliaro
- Claire Williams (ORCID: https://orcid.org/0000-0001-5467-149X)
- Carl J. Balibar (ORCID: https://orcid.org/0000-0003-0854-4224)
- Samuel H. Keller (ORCID: https://orcid.org/0000-0001-9931-3266)
- Bonnie J. Howell (ORCID: https://orcid.org/0000-0002-5915-9943)
- Jill W. Maxwell
- T. Rush
- Paul Zuck
- Liuliu Pan
- Kathy Ton
- Guoxin Wu (ORCID: https://orcid.org/0009-0008-8449-8155)
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Bruker (United States) (US)
- Nanostring Technologies (United States) (US)
Publication Details
- Journal
- Biomarker Research
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s40364-024-00658-x
- Citations
- 5
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47