4-(1H-Tetrazol-5-yl)-2-(p-tolyl)quinoline

The synthesis of 4-(1H-tetrazol-5-yl)-2-(p-tolyl)quinoline 4 as a possible modification of the biphenyltetrazole substructure of losartan 1 is described. The transformation of 2-(p-tolyl)quinoline-4-carbonitrile 3 to the corresponding tetrazole 4 was carried out by the reaction of trimethysilyl azide and dibutyltin oxide as a catalyst in refluxing toluene. The title compound (4) was characterized by IR, 1H NMR, 13C NMR, and HRMS.

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Publication Details

Journal
Molbank
Published
2024-10-08
DOI
https://doi.org/10.3390/m1897
Primary Topic
Synthesis of Tetrazole Derivatives
Type
article
Field-Weighted Citation Impact
0.00

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article

4-(1H-Tetrazol-5-yl)-2-(p-tolyl)quinoline

Angelika Lásiková, Daniel Végh
Molbank
Synthesis of Tetrazole Derivatives
article

4-(1H-Tetrazol-5-yl)-2-(p-tolyl)quinoline

Angelika Lásiková, Daniel Végh
article en

Abstract

The synthesis of 4-(1H-tetrazol-5-yl)-2-(p-tolyl)quinoline 4 as a possible modification of the biphenyltetrazole substructure of losartan 1 is described. The transformation of 2-(p-tolyl)quinoline-4-carbonitrile 3 to the corresponding tetrazole 4 was carried out by the reaction of trimethysilyl azide and dibutyltin oxide as a catalyst in refluxing toluene. The title compound (4) was characterized by IR, 1H NMR, 13C NMR, and HRMS.

MolbankVol. 2024(4)
Slovak University of Technology in Bratislava (SK)
Agentúra na Podporu Výskumu a Vývoja
Clean water and sanitation
Openalex Percentile: Top 87%
Synthesis of Tetrazole Derivatives
DOIOpen Access PDFOpenAlex
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4-(1H-Tetrazol-5-yl)-2-(p-tolyl)quinoline — Angelika Lásiková, Daniel Végh · Molbank (2024) | TGRS Research Map | TGRS