Genetically engineered human induced pluripotent stem cells for the production of brain-targeting extracellular vesicles
Taken together, we have established stable, genetically engineered hiPSCs for producing EVs with RVG expression, offering the improved ability for brain-targeted drug delivery.
Authors
- Hans B. Liu (ORCID: https://orcid.org/0000-0001-8911-5637)
- Fan Tang (ORCID: https://orcid.org/0000-0002-0068-8584)
- Guanshu Liu (ORCID: https://orcid.org/0000-0002-8188-4332)
- Chengqian Zhou (ORCID: https://orcid.org/0000-0003-0431-275X)
- Wenshen Wang
- Mingyao Ying (ORCID: https://orcid.org/0000-0002-6215-4959)
- Pan P. Li (ORCID: https://orcid.org/0000-0001-6084-6348)
- Tao Dong (ORCID: https://orcid.org/0000-0001-7578-3079)
- Leon Deng
Institutions
- Kennedy Krieger Institute (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Behavioral Pharma (United States) (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13287-024-03955-2
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Maryland Stem Cell Research Fund
- National Institute of Neurological Disorders and Stroke