Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium
β-cyclodextrins are good additives to stabilize siRNA in cell culture medium, and the thermodynamic data we generated of the interaction between cyclodextrins and adamantane analogs (widely used in drug delivery studies), should serve as a guide for future studies where cyclodextrins are sought for the delivery and solvation of small organic molecules.
Authors
- Pablo E. Vivas‐Mejía (ORCID: https://orcid.org/0000-0002-2001-857X)
- Betzaida Castillo Cruz
- Gabriel Barletta (ORCID: https://orcid.org/0000-0003-0016-901X)
- Olivier Pérez (ORCID: https://orcid.org/0000-0003-3961-8521)
- Sandra Chinapen Barletta
- Adriana S. Benitez-Reyes
- A. Amador
- B. Muñoz
Institutions
- University of Puerto Rico, Medical Sciences Campus (PR)
- University of Puerto Rico System (PR)
- University of Puerto Rico at Humacao (PR)
- San Juan Bautista School of Medicine (PR)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-08
- DOI
- https://doi.org/10.3390/ph17101344
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Institutes of Health
- National Institute of General Medical Sciences