N‐Acetyl‐L‐Cysteine (<scp>NAC</scp>) Blunts Axitinib‐Related Adverse Effects in Preclinical Models of Glioblastoma
Overall, we found that NAC co-treatment allows vessel normalization in brain tumor vessels and exerts a protective effect on liver vasculature, therefore minimizing axitinib-dependent toxicity.
Authors
- Manuela Pellegrini (ORCID: https://orcid.org/0000-0001-6387-5187)
- Maria Salbini (ORCID: https://orcid.org/0000-0003-1184-6629)
- Andrea Levi (ORCID: https://orcid.org/0000-0003-1863-1276)
- Stefano Giannetti (ORCID: https://orcid.org/0000-0002-6545-3401)
- Maria Patrizia Mongiardi (ORCID: https://orcid.org/0000-0002-5578-1751)
- Mariachiara Buccarelli (ORCID: https://orcid.org/0000-0003-1157-4694)
- Alessia Formato (ORCID: https://orcid.org/0000-0001-6720-1964)
- Maurizio Martini (ORCID: https://orcid.org/0000-0002-6260-6310)
- Valentina De Falco (ORCID: https://orcid.org/0000-0002-8972-7921)
- Elisa Orecchini (ORCID: https://orcid.org/0000-0002-0654-4696)
- Roberto Pallini (ORCID: https://orcid.org/0000-0002-4611-8827)
- Maria Laura Falchetti (ORCID: https://orcid.org/0000-0002-8755-0042)
- Quintino Giorgio D’Alessandris (ORCID: https://orcid.org/0000-0002-2953-9291)
- Liverana Lauretti (ORCID: https://orcid.org/0000-0001-7997-1624)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Messina (IT)
- Istituto Superiore di Sanità (IT)
- Agostino Gemelli University Polyclinic (IT)
- Neuroscience Institute (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Institute of Cell Biology and Neurobiology (IT)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/cam4.70279
- Citations
- 2
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Ministero della Salute