Highly Efficient Catalysis of Pyridinium p‐Toluenesulfonate (PPTS): Two Facile One‐Pot Protocols for the Synthesis of 2,3‐Disubstituted Quinazolinone Scaffolds

Abstract Two different one‐pot synthetic protocols have been developed for obtaining 2,3‐disubstituted quinazolin‐4(3 H )‐ones using pyridinium p ‐toluenesulfonate (PPTS) as catalyst. The two‐component reaction involves isatoic anhydride and N‐acetyl amine whereas the three‐component reaction use isatoic anhydride, aryl amine and β‐diketone in Toluene under classical heating at 80–100 °C to afford 2,3‐disubstituted quinazolin‐4(3 H )‐ones in good yields. The two‐component reactions are compatible with various substituted aryl/alkyl amines.