Light-Driven N-Heterocyclic Carbene-Catalyzed Multi-Component Reaction for the Synthesis of β-Amino Ketones
A N-heterocyclic carbene-catalyzed (NHC) three-component reaction involving <i>N</i>-aminopyridinium salts, alkenes, and aldehydes for the synthesis of β-amino ketones is described. In this reaction, <i>N</i>-aminopyridinium salts and the Breslow intermediate, which is generated from NHC and aldehydes, are utilized to undergo a single-electron transfer process, forming a ketyl radical intermediate and amidyl radicals. Subsequent to the formation of the amidyl radical, it undergoes selective capture by alkenes, followed by radical cross-coupling to yield the desired β-amino ketones.
Authors
- Wujiong Xia (ORCID: https://orcid.org/0000-0001-9396-9520)
- Chengcheng Shi (ORCID: https://orcid.org/0000-0001-6986-0752)
- Lin Guo (ORCID: https://orcid.org/0000-0002-2398-0684)
- Chao Yang (ORCID: https://orcid.org/0000-0003-1103-0056)
- Jiawen Yin
- Nan Zhong
Institutions
- Harbin Institute of Technology (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1021/acs.orglett.4c03288
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Science and Technology Foundation of Shenzhen City
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- State Key Laboratory of Urban Water Resource and Environment
- Basic and Applied Basic Research Foundation of Guangdong Province