Sirt6 ameliorates high glucose-induced podocyte cytoskeleton remodeling via the PI3K/AKT signaling pathway
Sirt6 protects podocytes against HG-induced cytoskeletal remodeling and apoptosis through activation of the PI3K/AKT signaling pathway. These findings provide evidence supporting the potential efficacy of Sirt6 activation as a promising therapeutic strategy for addressing podocyte injury in DKD.
Authors
- Zongwei Zhang (ORCID: https://orcid.org/0000-0002-6879-0470)
- Tao Yu (ORCID: https://orcid.org/0000-0002-0143-261X)
- Yanqin Fan (ORCID: https://orcid.org/0000-0002-3972-2188)
- Hongyan Liu (ORCID: https://orcid.org/0000-0003-3175-1029)
- Hao Huang (ORCID: https://orcid.org/0000-0002-3144-809X)
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- Wuhan University (CN)
- The First People's Hospital of Tianmen (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1080/0886022x.2024.2410396
- Citations
- 10
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- National Natural Science Foundation of China