Molecular Detection of Carbapenemases in Acinetobacter baumannii Strains of Portugal and Association With Sequence Types, Capsular Types, and Virulence
There are specific CRAB serotypes circulating in Portugal, accounting by the low diversity of acquired carbapenemase genes (OXA-23-like and OXA-40-like), ST types (ST2 and ST46) and KL types (KL2, KL7, KL9, and KL120) identified. The high prevalent of ST2, especially when associated with KL2 and bla<sub>OXA-23-like</sub>, suggest that antibiotic resistance has been driven by clonal expansion of clonal complex II. Such findings provide useful information on the diversity of multidrug-resistant bacterium that might be relevant for antibacterial interventions.
Authors
- Carina Almeida (ORCID: https://orcid.org/0000-0002-0175-1119)
- María José Saavedra (ORCID: https://orcid.org/0000-0002-7492-4965)
- Hugo Oliveira (ORCID: https://orcid.org/0000-0001-9564-5714)
- Charles M. A. P. Franz (ORCID: https://orcid.org/0000-0001-9726-1845)
- Daniela Araújo (ORCID: https://orcid.org/0000-0001-9830-0367)
- Rita Domingues (ORCID: https://orcid.org/0000-0003-0762-816X)
- Ricardo Oliveira (ORCID: https://orcid.org/0000-0001-9175-4278)
- Gyu‐Sung Cho (ORCID: https://orcid.org/0000-0002-3639-6663)
- Joana Azeredo
- Sónia Silva
Institutions
- University of Trás-os-Montes and Alto Douro (PT)
- Universidade do Porto (PT)
- Max Rubner Institut (DE)
- University of Minho (PT)
Publication Details
- Journal
- Clinical Therapeutics
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1016/j.clinthera.2024.09.005
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.02
Funders
- “la Caixa” Foundation
- Ministério da Ciência, Tecnologia e Ensino Superior
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Fundação para a Ciência e a Tecnologia