Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract
This comprehensive transcriptomic map of mouse EECs reveals patterns of GPCR and hormone co-expression that should be helpful in predicting the effects of nutritional and pharmacological stimuli on EECs from different regions of the gut. The finding that MC4R agonism stimulates CCK secretion adds to our understanding of the melanocortin system.
Authors
- Elisabeth O’Flaherty (ORCID: https://orcid.org/0000-0001-9056-5790)
- Fiona M. Gribble (ORCID: https://orcid.org/0000-0002-4232-2898)
- Tamana Darwish
- Alice E. Adriaenssens (ORCID: https://orcid.org/0000-0002-1279-4763)
- Frank Reimann (ORCID: https://orcid.org/0000-0001-9399-6377)
- Richard G. Kay (ORCID: https://orcid.org/0000-0002-3827-8687)
- Nunzio Guccio
- Joyce Li (ORCID: https://orcid.org/0000-0001-8112-2701)
- Rachel E. Foreman (ORCID: https://orcid.org/0000-0001-9491-6789)
- Jo E. Lewis (ORCID: https://orcid.org/0000-0002-5722-6778)
- Christopher A. Smith (ORCID: https://orcid.org/0000-0002-5035-6828)
- Austin Punnoose
Institutions
- University of Massachusetts Chan Medical School (US)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1371/journal.pone.0308942
- Citations
- 18
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Eli Lilly and Company
- AstraZeneca
- Wellcome Trust
- Cancer Research UK
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Cambridge Institute for Medical Research, University of Cambridge
- Cancer Research UK Cambridge Institute, University of Cambridge