Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase
Evidence suggests that high BC tissue (Cd, Co, Pb, Ni, Si) concentrations are associated with over-expressed MD genes, OS, p38-MAPK and low SOD2. These findings provide important understanding keys of probable carcinogenic pathways in BC associated with HMTE. So, efforts should be performed to minimize and counteract exposure to toxic HMTE.
Authors
- Heba H. Tarabay
- Bedeir Ali‐El‐Dein (ORCID: https://orcid.org/0000-0003-3811-2481)
- Mahmoud H. Abdelgawad (ORCID: https://orcid.org/0000-0002-1905-9040)
- Manar E. Elkady
- Mahmoud Laymon (ORCID: https://orcid.org/0000-0001-7929-0407)
- Ahmed Mosbah
- Mahmoud M. Zakaria (ORCID: https://orcid.org/0000-0002-7288-8374)
- Mona Abdel Rahim (ORCID: https://orcid.org/0000-0002-9235-7722)
- Tarek Mohamed (ORCID: https://orcid.org/0000-0003-1358-2110)
- Hazem H Saleh
- Arnolf Stenzl
Institutions
- Mansoura University (EG)
- University of Tübingen (DE)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1016/j.urolonc.2024.09.009
- Citations
- 5
- Primary Topic
- Chromium effects and bioremediation
- Type
- article
- Field-Weighted Citation Impact
- 1.57
Funders
- Ministry of Scientific Research, Egypt
- Science and Technology Development Fund