Effect of ACE mutations on blood ACE phenotype parameters
Conducting a systematic analysis of blood ACE levels in patients with ACE mutations holds promise for identifying individuals with low blood ACE levels. Such individuals may be at increased risk for late-onset AD. The patients with transport-deficient ACE mutations may benefit from therapeutic treatment with a combination of chemical and pharmacological chaperones and proteasome inhibitors, as was demonstrated previously using a cell model of the transport-deficient ACE mutation, Q1069R [Danilov et al, PLoS One, 2010].
Authors
- О. А. Кост (ORCID: https://orcid.org/0000-0001-9665-0523)
- Dmitriy Korostin (ORCID: https://orcid.org/0000-0003-1343-2550)
- I. V. Uporov (ORCID: https://orcid.org/0000-0003-3190-2851)
- Denis Rebrikov (ORCID: https://orcid.org/0000-0002-1884-1807)
- Steven M. Dudek
- Vera Belova (ORCID: https://orcid.org/0000-0001-5930-1965)
- Valery V. Cheranev (ORCID: https://orcid.org/0000-0001-5294-3033)
- Sergei M. Danilov (ORCID: https://orcid.org/0000-0002-6901-4545)
- Zhanna Repinskaia (ORCID: https://orcid.org/0009-0007-4228-6114)
- Olga V. Kryukova
Institutions
- Lomonosov Moscow State University (RU)
- Pirogov Russian National Research Medical University (RU)
- University of Illinois Chicago (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1371/journal.pone.0308289
- Citations
- 4
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Ministry of Science and Higher Education of the Russian Federation
- Lomonosov Moscow State University