Transition-Metal-Free Late-Stage Decarboxylative <i>gem</i>-Difluoroallylation of Primary Alkyl Acids
A transition-metal-free late-stage decarboxylative <i>gem</i>-difluoroallylation of carboxylic acids with α-trifluoromethyl alkenes has been described by the use of organo-photoredox catalysis. Both primary alkyl and heteroaryl acids were readily incorporated. This approach merits feedstock materials, mild reaction conditions, and wide functionality tolerance. The synthetic utility of this approach has been highlighted by the late-stage functionalization of a variety of acid-containing natural products and drug molecules.
Authors
- Qi Zhu (ORCID: https://orcid.org/0000-0003-1682-2087)
- Yue Zhang (ORCID: https://orcid.org/0000-0003-4292-3041)
- Zhen Chen (ORCID: https://orcid.org/0000-0002-6289-4332)
- Weiwei Fang (ORCID: https://orcid.org/0000-0002-2701-5216)
- Yumeng Zhang (ORCID: https://orcid.org/0000-0002-3194-347X)
- Xinyu Xie (ORCID: https://orcid.org/0009-0006-1765-0108)
- Xian Wei
- Ruofan Lin
Institutions
- Nanjing Forestry University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1021/acs.joc.4c02046
- Citations
- 7
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- Basic Research Program of Jiangsu Province