Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types
This study establishes that HRD can be directly predicted from H&E slides using attMIL, demonstrating its applicability across nine different tumor types.
Authors
- Hannah Sophie Muti (ORCID: https://orcid.org/0000-0002-3134-3837)
- Tobias Seibel (ORCID: https://orcid.org/0009-0004-9115-3228)
- Pier Selenica (ORCID: https://orcid.org/0000-0003-0086-0513)
- Kjong-Van Lehmann (ORCID: https://orcid.org/0000-0002-1936-298X)
- Alexandra Léary (ORCID: https://orcid.org/0000-0002-2043-2244)
- Marko van Treeck
- Marco Gustav (ORCID: https://orcid.org/0009-0009-3598-5720)
- Didem Çifçi (ORCID: https://orcid.org/0000-0002-2647-9959)
- Zunamys I. Carrero (ORCID: https://orcid.org/0000-0001-8501-1566)
- Jakob Nikolas Kather (ORCID: https://orcid.org/0000-0002-3730-5348)
- Omar S. M. El Nahhas (ORCID: https://orcid.org/0000-0002-2542-2117)
- Nadine Therese Gaisa (ORCID: https://orcid.org/0000-0002-4762-3964)
- Jorge S. Reis‐Filho (ORCID: https://orcid.org/0000-0003-2969-3173)
- Chiara Maria Lavinia Loeffler (ORCID: https://orcid.org/0009-0002-9659-5194)
- Kevin Bretz
- Nadina Ortiz-Bruechle
Institutions
- University of Leeds (GB)
- Memorial Sloan Kettering Cancer Center (US)
- Heidelberg University (DE)
- St James's University Hospital (GB)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- Integrated Oncology (United States) (US)
- National Center for Tumor Diseases (DE)
- University Hospital Cologne (DE)
- University Hospital Carl Gustav Carus (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s12915-024-02022-9
- Citations
- 13
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Deutscher Akademischer Austauschdienst
- Bundesministerium für Bildung und Forschung
- Technische Universität Dresden
- Bundesministerium für Gesundheit
- Deutsche Krebshilfe
- Gemeinsame Bundesausschuss
- Leeds Biomedical Research Centre