Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy
Our study proposes a mechanism for how tumor-infiltrating immune cells can promote cancer immune escape by dampening the IFN-I response. We suggest ARG1 and autophagy as putative therapeutic targets to activate the IFN-I response in tumors.
Authors
- Sonja Andersen
- Miriam S. Giambelluca (ORCID: https://orcid.org/0000-0003-0965-4943)
- Marina Vietri (ORCID: https://orcid.org/0000-0002-5859-322X)
- Apsana Lamsal (ORCID: https://orcid.org/0000-0001-6370-6324)
- Kristine Pettersen (ORCID: https://orcid.org/0000-0002-6446-0984)
- Geir Bjørkøy (ORCID: https://orcid.org/0000-0003-0031-8361)
- Marie‐Catherine Drigeard Desgarnier (ORCID: https://orcid.org/0000-0003-0755-6987)
- Camilla Wolowczyk (ORCID: https://orcid.org/0000-0002-8913-7462)
- Ida Johansson (ORCID: https://orcid.org/0000-0002-1404-9177)
- Nikolai Engedal (ORCID: https://orcid.org/0000-0003-3718-3464)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s12964-024-01858-6
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Trond Mohn stiftelse
- Helse Midt-Norge
- Norges Forskningsråd
- St. Olavs Hospital Universitetssykehuset i Trondheim