SMYD1 modulates the proliferation of multipotent cardiac progenitor cells derived from human pluripotent stem cells during myocardial differentiation through GSK3β/β-catenin&ERK signaling
Our research indicated that the participation of SMYD1 in the GSK3β/β-catenin&ERK signaling cascade modulated the proliferation of cardiac progenitor cells during myocardial differentiation. This process was partly reliant on the transcription of GSK3β. Our research provided a novel insight into the genetic modification effect of SMYD1 during early myocardial differentiation. The findings were essential to the molecular mechanism and potential interventions for congenital heart disease.
Authors
- Min Zhu (ORCID: https://orcid.org/0000-0001-6601-7575)
- Feng Lan (ORCID: https://orcid.org/0000-0002-9038-4014)
- Yun Chang (ORCID: https://orcid.org/0000-0003-0731-7943)
- Shuhong Ma (ORCID: https://orcid.org/0000-0002-9271-8030)
- Rui Bai
- Yongshuai Zhang (ORCID: https://orcid.org/0000-0001-8165-2446)
- Wenjing Lu (ORCID: https://orcid.org/0000-0003-4702-5777)
- Youxu Jiang
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Beijing Anzhen Hospital (CN)
- Fu Wai Hospital (CN)
- State Key Laboratory of Cardiovascular Disease
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13287-024-03899-7
- Citations
- 5
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Chinese Academy of Medical Sciences
- Shenzhen Fundamental Research Program
- Key Technologies Research and Development Program
- National Key Research and Development Program of China