Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
The early transition to an A + phenotype (A + T-N-) primarily impacts synaptic function. The appearance of T + and then N + is associated with a significant and progressive increase in pathological Alzheimer's disease biomarkers. Our main finding is that CSF pTau181 is an indicator of N + rather than T + , and that N + is associated with elevated levels of BACE1 protein and beta-amyloid peptides. This increase may potentially fuel the amyloid cascade in a positive feedback loop. Overall, our data provide further insights into understanding the interconnected pathological processes of amyloid, tau, and neurodegeneration underlying Alzheimer's disease.
Authors
- Olivier Hanon (ORCID: https://orcid.org/0000-0002-4697-122X)
- Susanna Schraen‐Maschke (ORCID: https://orcid.org/0000-0002-7247-4809)
- Audrey Gabelle (ORCID: https://orcid.org/0000-0002-7648-9194)
- Bernadette Allinquant (ORCID: https://orcid.org/0000-0002-6110-3746)
- Sylvain Lehmann (ORCID: https://orcid.org/0000-0001-6117-562X)
- Christophe Hirtz (ORCID: https://orcid.org/0000-0002-7313-0629)
- Jean‐Sébastien Vidal (ORCID: https://orcid.org/0000-0001-6770-0720)
- Luc Buée (ORCID: https://orcid.org/0000-0002-6261-4230)
- Constance Delaby (ORCID: https://orcid.org/0000-0002-8606-6814)
- Stéphanie Bombois
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Frederic Blanc
Institutions
- Universitat Autònoma de Barcelona (ES)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Hospital de Sant Pau (ES)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Institute for Regenerative Medicine & Biotherapy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Recherche Jean Pierre Aubert (FR)
- Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (FR)
- Hôpital Broca (FR)
- Hôpital Fernand-Widal (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut des Sciences Cognitives Marc Jeannerod (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Institute for Neurosciences of Montpellier (FR)
- Hôpital Saint Eloi (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Lille Neurosciences & Cognition (FR)
- Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologie (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13024-024-00755-3
- Citations
- 15
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.90