Disease coverage of human genome-wide association studies and pharmaceutical research and development
We produce target-disease indication lists to help the pharmaceutical industry to prioritize future drug development efforts based on genetic evidence, academia to prioritize future GWAS for diseases without effective treatments, and both sectors to harness genetic evidence to expand the indications for licensed drugs or to identify repurposing opportunities for clinical candidates that failed in their originally intended indication.
Authors
- Munir Pirmohamed (ORCID: https://orcid.org/0000-0002-7534-7266)
- Rory Maclean (ORCID: https://orcid.org/0000-0002-9686-0501)
- Ana Torralbo (ORCID: https://orcid.org/0000-0003-2738-8503)
- María Gordillo‐Marañón (ORCID: https://orcid.org/0000-0003-2993-6577)
- Amand F. Schmidt (ORCID: https://orcid.org/0000-0003-1327-0424)
- Jorgen Engmann (ORCID: https://orcid.org/0000-0001-7015-7773)
- C. R. Ytsma (ORCID: https://orcid.org/0000-0002-8333-6428)
- Christopher Tomlinson (ORCID: https://orcid.org/0000-0002-0903-5395)
- Reecha Sofat (ORCID: https://orcid.org/0000-0002-0242-6115)
- Claudia Langenberg (ORCID: https://orcid.org/0000-0002-5017-7344)
- Anoop D Shah (ORCID: https://orcid.org/0000-0002-8907-5724)
- Spiros Denaxas (ORCID: https://orcid.org/0000-0001-9612-7791)
- Aroon D. Hingorani (ORCID: https://orcid.org/0000-0001-8365-0081)
- Alasdair Warwick (ORCID: https://orcid.org/0000-0002-0800-2890)
- Chris Finan (ORCID: https://orcid.org/0000-0002-3319-1937)
- Harry Hemingway (ORCID: https://orcid.org/0000-0003-2279-0624)
Institutions
- University of Liverpool (GB)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- British Heart Foundation (GB)
- UCL Biomedical Research Centre (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Health Data Research UK (GB)
- Amsterdam University Medical Centers (NL)
- MRC Epidemiology Unit (GB)
- University College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1038/s43856-024-00625-5
- Citations
- 8
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Wellcome Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- HORIZON EUROPE Framework Programme
- Medical Research Council
- Engineering and Physical Sciences Research Council