α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Taken together, our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a proximal step in the cascade of events induced by aSYN pathology leading to dysfunction and degeneration of neurons at-risk in PD.
Authors
- Tatiana Tkatch (ORCID: https://orcid.org/0000-0001-6626-7435)
- Zhong Xie (ORCID: https://orcid.org/0000-0002-8348-4455)
- Jun Ueda (ORCID: https://orcid.org/0000-0002-6436-7923)
- Ted M. Dawson (ORCID: https://orcid.org/0000-0002-6459-0893)
- Enrico Zampese (ORCID: https://orcid.org/0000-0002-8851-2566)
- Valina L. Dawson (ORCID: https://orcid.org/0000-0002-2915-3970)
- Dalton James Surmeier (ORCID: https://orcid.org/0000-0002-6376-5225)
- David L. Wokosin (ORCID: https://orcid.org/0000-0002-5497-6944)
- Navdeep S. Chandel (ORCID: https://orcid.org/0000-0001-7208-3886)
- Elena Nasiri
- Wolfgang H. Oertel (ORCID: https://orcid.org/0000-0002-7582-8166)
- Martin T. Henrich (ORCID: https://orcid.org/0000-0001-8295-4884)
- Fanni F. Geibl (ORCID: https://orcid.org/0000-0002-5480-0463)
- Constantin A. Grotmann
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
- Philipps University of Marburg (DE)
- Johns Hopkins Medicine (US)
- Short and Associates (United States) (US)
- Research Network (United States) (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13024-024-00756-2
- Citations
- 53
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 19.56
Funders
- Michael J. Fox Foundation for Parkinson's Research
- JPB Foundation
- Von-Behring-Röntgen-Stiftung
- Gemeinnützige Hertie-Stiftung
- Stichting ParkinsonFonds
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke