Tumour reoxygenation after intratumoural hydrogen peroxide (KORTUC) injection: a novel approach to enhance radiosensitivity
Intratumoural KORTUC represents a novel oxygen delivery method, which can be exploited to enhance radiation response. If efficacy is confirmed in the ongoing phase 2 breast trial it could improve treatment of several tumour types where hypoxia is known to affect radiotherapy outcomes.
Authors
- Selvakumar Anbalagan (ORCID: https://orcid.org/0000-0001-6128-7998)
- Louise Howell (ORCID: https://orcid.org/0000-0002-4907-4188)
- Jessica K.R. Boult (ORCID: https://orcid.org/0000-0002-3990-9663)
- Navita Somaiah (ORCID: https://orcid.org/0000-0003-4609-0518)
- Carol Box (ORCID: https://orcid.org/0000-0002-8919-8724)
- John Yarnold (ORCID: https://orcid.org/0000-0002-9010-1854)
- Samantha Nimalasena
- Nigel Bush (ORCID: https://orcid.org/0000-0002-8137-7998)
- Victoria Sinnett
- William L. Murphy (ORCID: https://orcid.org/0000-0001-5577-7739)
- Simon P. Robinson (ORCID: https://orcid.org/0000-0003-4101-7274)
- Sheng Yu
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
Publication Details
- Journal
- BJC Reports
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1038/s44276-024-00098-y
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Royal Marsden NHS Foundation Trust
- Cancer Research UK
- National Institute for Health and Care Research