Superiority Trials in Invasive Aspergillosis: A Harsh Reality Check With the IA-DUET (HOVON502) Trial
The IA-DUET study aimed to compare azole-echinocandin combination therapy with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.
Authors
- Julien De Greef (ORCID: https://orcid.org/0000-0003-0200-1237)
- Sammy Huygens (ORCID: https://orcid.org/0000-0002-9418-8256)
- Tom Lodewyck (ORCID: https://orcid.org/0000-0002-7570-0656)
- Ine Moors (ORCID: https://orcid.org/0000-0003-3079-8909)
- Astrid Demandt (ORCID: https://orcid.org/0000-0003-4038-0231)
- Elena van Leeuwen-Segarceanu
- Maarten F. Corsten (ORCID: https://orcid.org/0000-0003-1326-4446)
- Maya Hites (ORCID: https://orcid.org/0000-0001-6961-6039)
- Laurens Nieuwenhuizen (ORCID: https://orcid.org/0000-0002-0494-9374)
- Bart J. A. Rijnders (ORCID: https://orcid.org/0000-0003-3343-9610)
- Robina Aerts (ORCID: https://orcid.org/0000-0001-6337-6636)
- Katrien Lagrou (ORCID: https://orcid.org/0000-0001-8668-1350)
- Sophie Servais (ORCID: https://orcid.org/0000-0002-0238-6379)
- Alexander Schauwvlieghe (ORCID: https://orcid.org/0000-0002-3224-3969)
- Johan A. Maertens (ORCID: https://orcid.org/0000-0003-4257-5980)
- Hanne Lamberink (ORCID: https://orcid.org/0000-0002-2304-1353)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Radboud University Nijmegen (NL)
- University of Liège (BE)
- Maastricht University Medical Centre (NL)
- Ghent University Hospital (BE)
- Erasmus MC (NL)
- University Medical Center (US)
- Maastricht University (NL)
- St. Antonius Ziekenhuis (NL)
- AZ Sint-Jan (BE)
- Máxima Medisch Centrum (NL)
- Meander Medisch Centrum (NL)
- Maastro Clinic (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1093/cid/ciae501
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- ZonMw