Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
These findings support the utility of a heparin-affinity approach coupled with TMT-MS for enriching amyloid-associated proteins, as well as a wide spectrum of plasma biomarkers that reflect pathological changes in the AD brain.
Authors
- Blaine R. Roberts
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Todd Eliot Golde (ORCID: https://orcid.org/0000-0003-1867-7071)
- Duc Minh Duong (ORCID: https://orcid.org/0000-0001-5880-1888)
- Luming Yin
- Anantharaman Shantaraman (ORCID: https://orcid.org/0000-0003-1384-941X)
- Lingyan Ping (ORCID: https://orcid.org/0000-0002-2623-5145)
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- Edward J. Fox
- Qi Guo (ORCID: https://orcid.org/0000-0003-2244-2101)
- Kaiming Xu
Institutions
- Emory University (US)
- Emory and Henry College (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13024-024-00757-1
- Citations
- 17
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Foundation for the National Institutes of Health
- National Institutes of Health