Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity
This study developed the first PGS for CIO using a large-scale hearing loss dataset and a biologically informed filter generated from cisplatin-treated murine inner ear snRNA-seq data. This innovative approach offers new avenues for developing PGSs for pharmacogenomic traits, which could contribute to the implementation of tailored therapeutic interventions. Further, our approach facilitated the identification of specific cochlear cells that may play critical roles in CIO. These novel insights will guide future research aimed at developing targeted therapeutic strategies to prevent CIO.
Authors
- MacKenzie A.P. Wilke (ORCID: https://orcid.org/0000-0002-7143-3853)
- Britt I. Drögemöller (ORCID: https://orcid.org/0000-0002-3348-5855)
- Jun Yang (ORCID: https://orcid.org/0000-0002-4233-3220)
- Deanne Nixie R. Miao (ORCID: https://orcid.org/0009-0008-5825-3074)
- Alain Dabdoub (ORCID: https://orcid.org/0000-0002-4259-2425)
- Janilyn Arsenio (ORCID: https://orcid.org/0000-0003-0220-0076)
- Feryal Ladha (ORCID: https://orcid.org/0009-0009-4231-0633)
- Emilia Luca
- Mansumeet Singh
- Wejian Yang
- John Pham (ORCID: https://orcid.org/0009-0001-8995-0840)
Institutions
- St. Jude Children's Research Hospital (US)
- Research Manitoba (CA)
- CancerCare Manitoba (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- Research Institute in Oncology and Hematology (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- University of Manitoba (CA)
Publication Details
- Journal
- Human Genomics
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s40246-024-00679-5
- Citations
- 3
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.08
Funders
- Health Sciences Centre Research Foundation
- Research Manitoba
- CancerCare Manitoba Foundation
- Children's Hospital Research Institute of Manitoba
- Canadian Institutes of Health Research