Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice
Our data provide evidence that the response of NfL in biofluids is influenced by the magnitude of mHTT lowering in the brain and the timing of intervention, suggesting that NfL may serve as a promising exploratory response biomarker for HD.
Authors
- David J. Hawellek (ORCID: https://orcid.org/0000-0002-2529-3351)
- Nicholas S. Caron (ORCID: https://orcid.org/0000-0002-3877-455X)
- Edward J. Wild (ORCID: https://orcid.org/0000-0002-6921-7887)
- Lauren M. Byrne (ORCID: https://orcid.org/0000-0003-1650-4273)
- Lorenzo Casal
- Christine Anderson (ORCID: https://orcid.org/0000-0002-3641-2192)
- Seung‐Hyun Ko (ORCID: https://orcid.org/0000-0003-3703-1479)
- Michael R. Hayden (ORCID: https://orcid.org/0000-0001-5159-1419)
- Amirah E.-E. Aly
- Peter McColgan (ORCID: https://orcid.org/0000-0002-5452-0648)
- Blair R. Leavitt (ORCID: https://orcid.org/0000-0002-4532-766X)
- Jeffrey N. Bone (ORCID: https://orcid.org/0000-0001-7704-1677)
- Fanny L. Lemarié (ORCID: https://orcid.org/0000-0002-9863-5105)
- Austin Hill
Institutions
- Roche (Switzerland) (CH)
- University of British Columbia (CA)
- Roche (United Kingdom) (GB)
- Pacific Centre for Reproductive Medicine (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- BC Children's Hospital (CA)
- University College London (GB)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s40035-024-00443-8
- Citations
- 6
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Huntington's Disease Society of America