5-ALA-peptide-gel with antibacterial repair effect on sports injury by low dose PDT

Acute wound injury is a common type of sports injury, and its local pathological changes are mainly traumatic inflammation, cell proliferation and tissue repair process, microvascular contraction often occurs briefly, vascular permeability increases, and water, electrolyte and plasma protein penetrate into the tissue space. Low-dose PDT (photodynamic therapy) promotes wound healing by promoting fibroblast migration, inducing instantaneous in-situ reactive oxygen species, promoting epidermal stem cell proliferation and migration, promoting dermal granulation tissue formation and angiogenesis, and regulating inflammatory processes. The CAR peptide, previously identified, was utilized as an adhesion molecule to facilitate the formation of tight junctions (TJ) and regulate intercellular adhesion among adjacent epithelial cells. Additionally, it was incorporated into the photosensitizer 5-ALA, presenting a novel antibacterial repair strategy for sports injuries.