The modulation of intestinal commensal bacteria possibly contributes to the growth and immunity promotion in Epinephelus akaara after feeding the antimicrobial peptide Scy-hepc
In summary, this study shows that feeding AMP Scy-hepc can promote growth and bolster immunity in E. akaara. These beneficial effects are likely due to the absorption of Scy-hepc in the fish's foregut and midgut, which modulates the colonization and motility of commensal bacteria, leading to favorable changes in the composition of the foregut and midgut microbiota. Therefore, a profound understanding of the mechanisms by which antimicrobial peptides affect host gut microbiota will contribute to a comprehensive assessment of their advantages and potential application prospects as substitutes for antibiotics in fish health and improving aquaculture practices.
Authors
- Hua Hao (ORCID: https://orcid.org/0000-0001-9292-2675)
- Luxi Wang (ORCID: https://orcid.org/0000-0002-7822-6566)
- Huiyun Chen (ORCID: https://orcid.org/0000-0002-7671-2616)
- Hang Sun (ORCID: https://orcid.org/0000-0003-1565-0308)
- Ke-Jian Wang
- Wenbin Zheng
- Xiangyu Meng (ORCID: https://orcid.org/0000-0001-5395-5642)
- Hui Peng (ORCID: https://orcid.org/0000-0002-9221-385X)
- Fangyi Chen (ORCID: https://orcid.org/0000-0001-5714-1339)
Institutions
- Xiamen University (CN)
- Xiamen University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Animal Microbiome
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s42523-024-00342-3
- Citations
- 4
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Fujian Province
- Xiamen University