Primary Progressive Aphasia Lacking Core Features of Nonfluent and Semantic Variants
This observed clinical heterogeneity reflects different time points/severities of the same disease process and hence can be reconceptualized as an AD-related aphasia spectrum, incorporating lvPPA and the 4 subgroups (pure-LPA, Wernicke-like, anomic-like, and TCSA-like). Specifying moderate/severe repetition deficits as a core feature of lvPPA in the 2011 consensus criteria can enhance its pathologic correlations. Recognizing progressive anomic aphasia (anomic-like) as an additional PPA variant could lessen pathologic heterogeneity of lvPPA.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Heather M. Clark (ORCID: https://orcid.org/0000-0001-9697-0084)
- Joseph R. Duffy (ORCID: https://orcid.org/0000-0001-8206-3432)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Nha Trang Thu Pham
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
- Watanabe Hiroyuki (ORCID: https://orcid.org/0009-0009-1623-6599)
Institutions
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1212/wnl.0000000000209924
- Citations
- 9
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- National Institutes of Health