Characterization of Clinical Course and Response to Treatment on Cerebral Amyloid Angiopathy-Related Inflammation

31.5%) tubercular, 4 (3.9%) each rickettsial, atypical bacteria, fungal, and 3 (2.9%) were parasitic.Among non-infectious etiologies, 12 (11.8%)were antineuronal antibody-mediated, 3 (2.9%) were systemic inflammatory, and one (1%) had carcinomatous meningitis.CSF analysis showed the highest protein content (336.82251.26mg/ dl) and cell count (476.73999.16) in pyogenic.CSF glucose was lowest in tubercular (38.3020.29 mg/dl).On imaging, leptomeningeal enhancement was found in 89.7% of tubercular and limbic involvement more often in viral (38.5%) etiology.Overall mortality was highest in fungal and rickettsial (75% each).Fever, altered sensorium, speech disturbances, neck stiffness, albumin, total leukocyte count, ESR, CRP, kidney, and liver function tests showed significant association with mortality. ConclusionsTubercular was the most common cause in our centre in Western India.The atypical bacterial, parasitic, and systemic inflammatory groups had the best recovery at discharge.However, tubercular, atypical bacterial, and antineuronal antibody-mediated meningoencephalitis was associated with a significant change in mRS score over time.

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Publication Details

Journal
Neurology
Published
2024-10-08
DOI
https://doi.org/10.1212/01.wnl.0001051532.55252.dc
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
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article

Characterization of Clinical Course and Response to Treatment on Cerebral Amyloid Angiopathy-Related Inflammation

Bart K. Chwalisz, Lucas Horta, Bruna Leles Vieira de Souza
Neurology
Intracerebral and Subarachnoid Hemorrhage Research
article

Characterization of Clinical Course and Response to Treatment on Cerebral Amyloid Angiopathy-Related Inflammation

Bart K. Chwalisz, Lucas Horta, Bruna Leles Vieira de Souza
article en

Abstract

31.5%) tubercular, 4 (3.9%) each rickettsial, atypical bacteria, fungal, and 3 (2.9%) were parasitic.Among non-infectious etiologies, 12 (11.8%)were antineuronal antibody-mediated, 3 (2.9%) were systemic inflammatory, and one (1%) had carcinomatous meningitis.CSF analysis showed the highest protein content (336.82251.26mg/ dl) and cell count (476.73999.16) in pyogenic.CSF glucose was lowest in tubercular (38.3020.29 mg/dl).On imaging, leptomeningeal enhancement was found in 89.7% of tubercular and limbic involvement more often in viral (38.5%) etiology.Overall mortality was highest in fungal and rickettsial (75% each).Fever, altered sensorium, speech disturbances, neck stiffness, albumin, total leukocyte count, ESR, CRP, kidney, and liver function tests showed significant association with mortality. ConclusionsTubercular was the most common cause in our centre in Western India.The atypical bacterial, parasitic, and systemic inflammatory groups had the best recovery at discharge.However, tubercular, atypical bacterial, and antineuronal antibody-mediated meningoencephalitis was associated with a significant change in mRS score over time.

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Intracerebral and Subarachnoid Hemorrhage Research
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