Employment and its Associations in an International Cohort of Myelin Oligodendrocyte Glycoprotein Antibody Disease

syndrome) is a rare neuro-inflammatory disorder predominantly affecting the brain's supratentorial regions. Design/MethodsThe case series draws on a detailed review of clinical data for two patients who were monitored at Ochsner Health, ensuring a comprehensive and insightful analysis of their medical journeys for this study. ResultsCase 1 details a 25-year-old man with a history of asthma and childhood seizures, presenting with a generalized tonic-clonic seizure.MRI revealed a heterogeneously enhancing lesion in the left frontal lobe.Despite normal cerebrospinal fluid (CSF) analysis, a biopsy indicated peri-vascular T-cell predominant inflammation.Steroid treatment was initiated, yielding a positive response.Case 2 involves a 19-year-old woman with no significant past medical history who experienced druginduced seizures and developed progressive neurological symptoms.Her MRI demonstrated T2 FLAIR hyperintensities with enhancement, indicating an inflammatory process.Biopsy showed reactive T-cell perivascular inflammation.The patient's condition evolved, requiring increased steroid treatment and adjunctive rituximab therapy.Both cases involved initial seizure control with levetiracetam and demonstrated clinical improvement with steroids, supporting an inflammatory etiology.However, the cases differed in their progression and complexity of diagnosis. ConclusionsIn summary, these cases highlight the diverse manifestations of SLIP-PERS syndrome, ranging from isolated lesions with autoimmune features to more elusive, progressive patterns requiring extensive investigation and treatment adjustments.This series emphasizes the need for clinical vigilance to facilitate early detection and treatment of SLIPPERS syndrome, a condition with diverse symptoms and considerable diagnostic hurdles.These cases add to the evidence aiding comprehension of SLIPPERS syndrome's clinical and pathological characteristics.Study Supported By: N/A.

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Publication Details

Journal
Neurology
Published
2024-10-08
DOI
https://doi.org/10.1212/01.wnl.0001050960.45638.92
Citations
1
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.24

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article

Employment and its Associations in an International Cohort of Myelin Oligodendrocyte Glycoprotein Antibody Disease

Andrew Siyoon Ham, Melih Tütüncü, Raffaele Federico Iorio, Shanthi Viswanathan et al.
1 citations
Neurology
T-cell and B-cell Immunology
0.24
article

Employment and its Associations in an International Cohort of Myelin Oligodendrocyte Glycoprotein Antibody Disease

Andrew Siyoon Ham, Melih Tütüncü, Raffaele Federico Iorio, Shanthi Viswanathan, Y Muralidhar Reddy, Patricia Jane Kelly, Akshatha Sudhir, Eleonora Sabatelli, Saúl Reyes, Unnah Leitner, Juan Ignacio Rojas, Kevin Tan, Saif Huda, Lekha Pandit, Bade Güleç, Lu Wen, Hongfei Gu, Simon Broadley, Aksel Sıva, Edgardo Cristiano, Jaime Toro, Uğur Uygunoğlu, Farrah Jasmine Mateen, Karina Koh, Tianrong Yeo, Enedina Maria Lobato de Oliveira, Amelia Yun Yi Aw, Jairo Gaitán, Su‐Yin Lim, De‐Cai Tian, Raquel Paiva Portugal, Isabella Gomez Hjerthen, Raúl Comme-Debroth, Paloma Peter Travassos Zaidan, Deyanira Altagracia Ramírez, Liliana Patrucco, Jagarlapudi M. K. Murthy, Josmarlin Patricia Medina Báez
article en
1 citations

Abstract

syndrome) is a rare neuro-inflammatory disorder predominantly affecting the brain's supratentorial regions. Design/MethodsThe case series draws on a detailed review of clinical data for two patients who were monitored at Ochsner Health, ensuring a comprehensive and insightful analysis of their medical journeys for this study. ResultsCase 1 details a 25-year-old man with a history of asthma and childhood seizures, presenting with a generalized tonic-clonic seizure.MRI revealed a heterogeneously enhancing lesion in the left frontal lobe.Despite normal cerebrospinal fluid (CSF) analysis, a biopsy indicated peri-vascular T-cell predominant inflammation.Steroid treatment was initiated, yielding a positive response.Case 2 involves a 19-year-old woman with no significant past medical history who experienced druginduced seizures and developed progressive neurological symptoms.Her MRI demonstrated T2 FLAIR hyperintensities with enhancement, indicating an inflammatory process.Biopsy showed reactive T-cell perivascular inflammation.The patient's condition evolved, requiring increased steroid treatment and adjunctive rituximab therapy.Both cases involved initial seizure control with levetiracetam and demonstrated clinical improvement with steroids, supporting an inflammatory etiology.However, the cases differed in their progression and complexity of diagnosis. ConclusionsIn summary, these cases highlight the diverse manifestations of SLIP-PERS syndrome, ranging from isolated lesions with autoimmune features to more elusive, progressive patterns requiring extensive investigation and treatment adjustments.This series emphasizes the need for clinical vigilance to facilitate early detection and treatment of SLIPPERS syndrome, a condition with diverse symptoms and considerable diagnostic hurdles.These cases add to the evidence aiding comprehension of SLIPPERS syndrome's clinical and pathological characteristics.Study Supported By: N/A.

NeurologyVol. 103(7_Supplement_1)
Sanofi, Biogen, Biogen Idec, Alexion Pharmaceuticals, Horizon Therapeutics, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, Genentech, EMD Serono
Decent work and economic growth
Openalex Percentile: Top 42%
T-cell and B-cell Immunology
0.24
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