MDVarP: modifier ~ disease-causing variant pairs predictor
MDVarP prioritizes variant pairs associated with phenotypic modulations, enabling more effective mapping of functional contributions from disease-causing and modifier variants. This framework interprets genetic interactions underlying phenotypic variations in human diseases, with potential applications in personalized medicine and disease prevention.
Authors
- Liangxiao Ma (ORCID: https://orcid.org/0000-0002-9103-4913)
- Yunqin Chen (ORCID: https://orcid.org/0000-0002-8619-0890)
- Hong Sun (ORCID: https://orcid.org/0000-0003-1306-7629)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- BioData Mining
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1186/s13040-024-00392-y
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00