Molecular and clinical heterogeneity within <i>MYC</i>-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study
MYC(N)-amplified MB displays significant clinicobiological heterogeneity. Diagnostics incorporating molecular groups, subgroups, and clinical factors enable their risk assessment. VHR "canonical" MYC tumors are essentially incurable and SHH-MYCN-amplified MBs fare extremely poorly (20% survival at 5 years); both require urgent development of alternative treatment strategies. Conventional risk-adapted therapies are appropriate for more responsive groups, such as noncanonical MYC and non-SHH-MYCN MB.
Authors
- Stephen Crosier
- Marina Danilenko (ORCID: https://orcid.org/0009-0007-1227-8674)
- Sarra Ryan (ORCID: https://orcid.org/0000-0002-5507-0060)
- Till Milde (ORCID: https://orcid.org/0000-0002-7267-1052)
- Debbie Hicks (ORCID: https://orcid.org/0000-0002-7551-7464)
- Andrey Korshunov (ORCID: https://orcid.org/0000-0002-5257-3623)
- Stefan M. Pfister (ORCID: https://orcid.org/0000-0002-5447-5322)
- Jemma Castle
- Rebecca M. Hill (ORCID: https://orcid.org/0000-0001-8405-2219)
- Simon Bailey (ORCID: https://orcid.org/0000-0001-9348-5497)
- Steven C. Clifford (ORCID: https://orcid.org/0000-0003-4893-2184)
- Janet C. Lindsey (ORCID: https://orcid.org/0000-0002-5043-7513)
- Marcel Kool (ORCID: https://orcid.org/0000-0002-6557-5468)
- Ed C. Schwalbe (ORCID: https://orcid.org/0000-0002-1190-9469)
- Daniel Williamson
Institutions
- German Cancer Research Center (DE)
- Utrecht University (NL)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Northumbria University (GB)
- National Center for Tumor Diseases (DE)
- Hopp Children's Cancer Center Heidelberg (DE)
- Princess Máxima Center (NL)
- Health & Life (Taiwan) (TW)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Newcastle University (GB)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-10-08
- DOI
- https://doi.org/10.1093/neuonc/noae178
- Citations
- 21
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.20
Funders
- Deutsches Krebsforschungszentrum
- Northumbria University
- Cancer Research UK
- Newcastle University
- CHILDREN with CANCER UK
- Brain Tumour Charity
- Universiteit Utrecht
- Deutschen Konsortium für Translationale Krebsforschung
- Universitätsklinikum Heidelberg
- Medical Research Council