The Future of OOC on Neurological Diseases - Alzheimer's

Abstract: Neurological Diseases such as Alzheimer's and Parkinsons' have been deemed incurable diseases. The complexity of the human brain is an obstacle for scientists to understand how treatments could interact with human brain microenvironments. To this date, researchers have used traditional modeling methods, such as in vitro cell culture and in vivo animal models. These methods are unable to showcase the different layers of the blood-brain barrier or accurately represent the cellular interactions within the brain. The proposed solution is a new research technology, organ on a chip, a multi-organ system connected with microfluidics. This review explores the organ on a chip, what it is made for, and how it is the future of drug development. In addition, we explore the lymphatic system and the different organ-on-a-chip models that can simulate the lymphatic system and BBB. Organ on a chip has the potential to help efficiently develop drugs and treatment, which has the potential to improve neurological disease conditions.